The link between PGC-1α and renal disease was recently explored in two studies by Tran et al. [22,33], where the authors show that deletion of PGC-1α specifically in the renal proximal tubules leads to a worsened renal phenotype in mice during acute ischemic kidney injury [22] while overexpression of PGC-1α helps to protect against damage [33]. Here, PPARGC1A is linked to kidney injury.