However, in line with the predicted increase in NF-κB activity, HFD-fed NiPKO mice displayed several KEGG terms enriched amongst their upregulated genes that were associated with inflammation and immune response, such as primary immunodeficiencies (mmu05340), the JAK/STAT pathway (mmu04630) and Toll-like receptor signaling pathway (mmu04620) (Fig 7B, S5 Table). The gene discussed is NFKB1; the disease is inborn error of immunity.