According to gene expression profiles, in the 80 samples considered – composed of 23 normal colon mucosa (Normal), 30 primary colon carcinoma (CRC) and 27 liver metastases (Mts) – the expression of ZFP36 gene is significantly decreased when comparing primary tumour with normal counterpart (Figure 1A). The gene discussed is ZFP36; the disease is colorectal carcinoma.