Since highly malignant MM cells show a reduced dependency on signals provided by the BM, at least in part due to the cell-autonomous production of IL-6 [6, 8], we wondered if the upregulation of Notch signaling could play a role in promoting the malignant progression of MM cell by reducing the dependency on signals provided by BM such as IL-6. The gene discussed is IL6; the disease is Miyoshi myopathy.