As shown in Figure 6C and 6D, these results confirmed a positive correlation between the expression of IL-6 and HES1 (r = 0.57 and p = 2.28×10-4) and showed IL-6 and HES1 gene expression upregulation upon stimulation of mesenchymal cells with MM1S myeloma cells. The gene discussed is HES1; the disease is plasma cell myeloma.