JAG1 and Miyoshi myopathy: This hypothesis was verified in our CMA-03 model of MM progression, demonstrating that: 1) the acquisition of IL-6 independent cell growth was associated with the upregulated expression of Notch receptors and ligands together with increased transcription of Notch target genes; 2) when stimulated with soluble JAGGED1 ligands, IL-6-dependent CMA-03 cells acquired the ability to grow in the absence of IL-6; and 3) upon DAPT administration, IL-6-independent and unresponsive CMA-03/06 cells recovered IL-6 dependency.