CYCS and viral infectious disease: One possible mechanism is that the segregation and degradation of damaged mitochondria resulting from PRRSV infection by mitochondrial fission and mitophagy may delay the induction of apoptosis by preventing the release of cytochrome C. In summary, this study provides evidence that PRRSV hijacks host signaling pathway by inducing mitochondrial fission and mitophagy to facilitate persistent viral infection which extend our knowledge about the pathology of PRRSV infection.