CD8A and neoplasm: As for the immune cells markers detected by IHC, the presence of CD8+ cells in the tumor compartment, according to the median of positive cells infiltrating the tumor, was significantly associated with better PFS (56.8 vs. 23 months, p = 0.026) and OS (73.9 vs. 40.4 months, p = 0.021; Figure 2A-2B), whereas patients with a higher percentage of FOXP3+ cells in the stromal compartment (more that 10% of positive lymphocytes) had shorter OS (37.2 vs. 68 months, p = 0.029; Figure 2C-2D; Table 2).