CD4 and neoplasm: Univariate survival analyses showed that patients with high FOXP3+ cells infiltration (more than 10% of positive lymphocytes) in the stroma and low CD4+ cells infiltration in the tumor (according to the median of positive cells infiltrating in the tumor) presented significantly worse OS (17.4 vs. 66.9 months, p = 0.024; Figure 4A-4B; Table 2).