The unspecific accumulation of the antibody in breast tumors could be due to the enhanced permeability and retention (EPR) effect, which is characterized by a leaky nature of tumor vasculature and reduced lymphatic drainage [61], rather than an involvement of the vasculature since LEM2/15 showed no reactivity with most of the mouse tumor blood vessels by IHC. The gene discussed is LEMD2; the disease is neoplasm.