However, to the best of our knowledge, this is the first time that a MT1-MMP-based immunoPET is described for GBM detection and it is expected to have greater performance than other MT1-MMP-based imaging systems developed up to now: immunoPET combines the antibody characteristics of high specificity, affinity and great structural flexibility to generate a variety of fragments with half-lives matching optimally the period of semi-desintegration of isotopes, with PET as imaging technique which provides higher spatial resolution and sensitivity than SPECT from a clinical perspective. Here, MMP14 is linked to glioblastoma.