Membrane type 1-Matrix Metalloproteinase (MT1-MMP, also known as MMP14) has emerged as an attractive biomarker for tumor-targeted antibody development since this protein is crucial for the progression, invasion, migration and angiogenesis of tumors[12,13]; and specifically, its expression correlates with tumor grade and it is associated with reduced survival in gliomas[14,15] and other cancers[16]. Here, MMP14 is linked to central nervous system cancer.