CXCL8 and neoplasm: This hypoxic microenviroment, not only contributes to pro-fibrogenic activity of PSCs but stimulates PSCs to produce several angiogenic molecules, including VEGF, fibroblast growth factor-2 (FGF-2), platelet derived growth factor (PDGF), interleukin-8 (IL-8), MMP-9, and vasohibin-1, resulting in foci of angiogenesis in the peripheral areas of the tumor [14–15] (Figure 1).