The Wnt effector beta-catenin is a transcriptional co-activator that can also mutate to a potent oncogene, while the canonical Wnt signaling pathway stabilizes beta-catenin transcription.(4,5) Mutations and the overexpression of beta-catenin are associated with many cancers, including hepatocellular carcinoma, colorectal carcinoma, lung cancer, malignant breast tumors, and ovarian and endometrial carcinomas.(6). The gene discussed is CTNNB1; the disease is lung cancer.