Axin 1 has emerged as a major scaffold protein for regulating a variety of signaling pathways and biological functions.(24) The human homolog gene of axin 1 was mapped to chromosome 16p13.3.(25) In sporadic CRC, an increased expression of axin protein suggests that mutation of the corresponding gene can participate in colorectal carcinogenesis.(26,27) In this way, the present study observed that the staining of the mutated protein GSK3β in CRC was significantly increased with respect to the non-neoplastic adjacent mucosa. This evidence concerns the gene GSK3B and colorectal carcinoma.