Alternatively, rs1034528 and rs17036508 are respectively located in 5′ upstream region and 3′-UTR of the angiopoietin-like 7 gene (ANGPTL7), itself within intron 28 of mTOR. ANGPTL7 expression was reported to be up-regulated by hypoxia in cancer cells and to exert a pro-angiogenetic effect, which is essential in the early stages of tumor development [52]. Here, ANGPTL7 is linked to neoplasm.