Rescue experiments with MACC1 overexpression or knock-down of MACC1 and miR-218 clearly revealed that MACC1 as a novel target of miR-218 is at least in part responsible for the significant reduction of migration, invasion and colony formation by miR-218 in CRC and gastric cancer cell lines [1, 15, 17]. The gene discussed is MACC1; the disease is colorectal carcinoma.