Consistent with these results, interestingly the down-regulation of STAT3 also decreased the invasiveness and motility (Supplementary Figure S3B) and the expression of the epithelial marker such as E-cadherin was reappeared while the mesenchymal markers such as N-cadherin and vimentin were lost in irradiated MCF7 breast cancer cells (Supplementary Figure S3C and S3D). This evidence concerns the gene CDH2 and breast carcinoma.