To this end, we sequenced and annotated the genome of Ad43, compared its structure with those of other Ads, ascertained the biodistribution of intravenously injected Ad43 virions, designed a plasmid-based system that facilitates molecular manipulations with Ad43 genome, identified Ad43's primary receptors, and successfully modified the primary receptor specificity of Ad43 fiber to enable infection via human epidermal growth factor receptor type 2 (Her2), a recognized oncotarget. The gene discussed is ERBB2; the disease is infection.