EIF4E and acute myeloid leukemia: MNKI-8e, a derivative of 5-(2-(phenylamino)pyrimidin-4-yl)thiazol-2(3H)-one, inhibited Mnk2 activity, blocked phosphorylation of eIF4E, downregulated anti-apoptotic protein Mcl-1 and induced apoptosis in AML cells [17].