MKNK1 and acute myeloid leukemia: In the current work, MNKI-8e and short hairpin RNA (shRNA) mediated knockdown of Mnk1 and Mnk2, i.e. Mnk1 KD and Mnk2 KD, as well as double knockdown of Mnk1&2, i.e. Mnk1&2 KD, were used to investigate the mechanisms of action in AML cells.