In addition, miR-133a targeting of EGFR, miR-200c and miR-30c targeting of KRAS, miR-148b targeting of NRAS, miR-7 targeting of RAF1, miR-206 targeting of RASA1 and miR-21 targeting of SPRED1 have been reported in breast cancer cells [26]. The gene discussed is SPRED1; the disease is breast cancer.