RNF43 and colorectal cancer: It acts oncogenically by reducing two potential tumor suppressors, element binding protein 4 (CPEB4) in hepatocellular carcinoma [46] and ring finger 43 (RNF43) in colorectal cancer [47]; however, it also acts as a tumor-suppressor by directly targeting the 3’-UTR of the oncogene hepatocyte nuclear factor 1β (HNF1B) [48].