MAPK1 and breast carcinoma: As shown in Supplementary Table S2, miR-550a-3p (p < 0.001) was significantly lower in breast cancer samples than benign breast disease samples; ERK1 (p = 0.036), ERK2 (p = 0.011) and p-ERK1/2 (p = 0.007), on the other hand, were significantly increased in the breast cancer samples relative to benign breast disease samples.