To our knowledge, only three miRNAs had been suggested to directly target ERKs: miR-483-5p targets MAPK3 (ERK1) in gliomas [43], miR-524-5p targets MAPK1 (ERK2) in melanoma [44], and the miR-124/214 cluster targets both ERKs in squamous cell carcinoma; miR-214 targets MAPK3 (ERK1) whereas MAPK1 (ERK2) is regulated by both miR-124 and miR-214 [45]. This evidence concerns the gene MAPK3 and central nervous system cancer.