Additionally, they detected elevated PZ expression in tissue-associated macrophages and endothelial cells in cancer microenvironments, and examined the expression and interactions of PZ, ZPI, prothrombin fragments (F1 + 2), and fibrin in non-small-cell lung carcinoma and colon cancer (Sierko et al. 2011, 2012a, b). Here, F2 is linked to cancer.