In addition, phosphoglycerate dehydrogenase, which diverts glycolytic carbon to serine and glycine metabolism, is overexpressed in melanoma and some types of breast cancer, and ectopic expression of phosphoglycerate dehydrogenase confers MCF-10A mammary epithelial cells with the ability to resist anoikis [12]. The gene discussed is PHGDH; the disease is breast carcinoma.