As shown in Figure 4b, our analysis for 3ʹUTR-APAs included genes involved in different biological pathways (Supplementary Table S1) with functions in DDR and cancer, such as small nuclear ribonucleoprotein polypeptide B (SNRPB2) [36, 37], endoplasmic reticulum protein retention receptor 1 (KDELR1) [38, 39]; Notch homolog 1 translocation-associated (NOTCH1) [40, 41] and dual specificity phosphatase 6 (DUSP6) [42, 43]. This evidence concerns the gene NOTCH1 and cancer.