Thus, current RNA-seq data provide compelling evidence that UHRF1 and to less extent UHRF2 are overexpressed in various cancers and its overexpression appears to correlate with DNA hypomethylation phenotype in cancer, raising the possibility that UHRF1/2 overexpression would downregulate DNMT3A proteins and consequently lead to DNA hypomethylation phenotypes in cancers. This evidence concerns the gene DNMT3A and cancer.