UHRF2 and breast carcinoma: Furthermore, while knockdown of either UHRF1 or UHRF2 led to increased DNMT3A, a more pronounced increase of DNMT3A was observed when both UHRF1 and UHRF2 were knocked down in the MDA-231 breast cancer cell line (Figure 3f), indicating that UHRF1 and UHRF2 cooperatively regulate DNMT3A.