To test if UHRF1/2 overexpression indeed leads to downregulation of DNMT3A proteins in cancers despite DNMT3A overexpression at the level of transcription (Figure 5c), we next examined the levels of UHRF1, UHRF2 and DNMT3A proteins in paired lung tumors and adjacent normal controls by western blot analysis. Here, UHRF1 is linked to cancer.