Moreover, in CT-26 tumor bearing mice, messenger RNA (mRNA) levels of atrogenes, MAFbx, and MuRF1 were significantly up-regulated in skeletal muscles, and those increases were significantly inhibited by everolimus or by the combination with CDD866 while CDD866 only displayed a trend towards reducing MuRF1 (Fig. 11b, c). The gene discussed is TRIM63; the disease is neoplasm.