Because SHBG is inversely related to BMI beginning in childhood, and is a marker for insulin resistance and the risk for developing T2DM [1], we hypothesized that SHBG levels at birth might represent a biomarker of fetal metabolic status, and might be related to the newborn’s Ponderal index or skin fold thickness, or might correlate with maternal obesity or pregnancy weight gain. The gene discussed is SHBG; the disease is Insulin resistance.