Age and total body fat entered into the regression and were related to vaspin in the presence of MetS (F [2, 113] = 7.86 (2, 113), p = 0.001), total body fat was related to vaspin in NDT2D (F [1, 33] = 6.01, p < 0.020), parasympathetic tone during deep breathing was related to vaspin in NGT–MetS (F [1, 33] = 8.92, p < 0.005), and sympathetic tone at rest was related to vaspin in NGT + MetS (F [1, 33] = 5.36, p < 0.027). This evidence concerns the gene SERPINA12 and metabolic syndrome.