Therefore, we investigated the effect of empagliflozin and that of linagliptin, a DPP-4 inhibitor, on steatohepatitis and fibrosis in a new mouse model of NASH with a diabetic background, which was generated by administration of streptozotocin (STZ) to C57BL/6J mice at 2 days old combined with a high-fat diet from the age of 4 weeks [17]. Here, DPP4 is linked to metabolic dysfunction-associated steatohepatitis.