Shortest pathways (Fig. 8) between the Asthma node and the core clock genes (Table 3) node include: a) Asthma – Q9UIL8 – P67870 – Q99743; b) Asthma – P84022 – Q99814 – O00327; c) Asthma – P01374 – Q92956 – O15055; d) Asthma – [P09211, P01375, P13569] – [Q12933, P28799] – Q16526. The gene discussed is CLOCK; the disease is asthma.