Among Czech IPF cases, (i) SNP rs12602273 located in intron of TP53 that regulates cell-cycle arrest; while, (ii) rs4277405 and (iii) rs4459609 located in promoter region of ACE-II suggested with critical profibrotic role in IPF (28, 29) were observed. The gene discussed is TP53; the disease is idiopathic pulmonary fibrosis.