In contrast to these results, we and others have reported that PI3KAP/XB130 was localized to lamellipodia in thyroid carcinoma cells (16) and to lamellipodia-like cortical actin structures in non-transformed thyroid follicular cells (12), suggesting that intracellular localization of this protein was not restricted to lamellipodia but was dependent on actin filament structures. Here, AFAP1L2 is linked to thyroid gland carcinoma.