ACE2 and hydrops fetalis: It is noteworthy that maternal HF intake has a distinct sex-specific effect on the renal RAS system at 1 week of age, immediately after the completion of nephrogenesis: Maternal HF up-regulated Ren (FC = 2.07) and Agt (FC = 2.6) in male offspring, while up-regulated Ace2 (FC = 2.02) and Mas1 (FC = 2.77) in female offspring.