The key findings are as follows: (1) maternal HF intake induces programmed hypertension in 12-week-old offspring of both sexes, (2) maternal HF intake induces a greater change in renal transcriptome in females than males at 1 week of age, (3) renal mRNA expression of the RAS components in differ between male and female offspring, (4) aliskiren administration during early postnatal life prevents HF-induced programmed hypertension in both sexes of adult offspring and (5) aliskiren administration increased ACE2 and MAS protein levels in female kidneys exposed to maternal HF intake. The gene discussed is MAS1; the disease is hydrops fetalis.