Interestingly, CuZn-SOD overexpression protects the aorta from lipid peroxidation and DNA fragmentation, whereas Mn-SOD heterozygous-deficient mice exhibited enhanced aortic lipid peroxidation and apoptosis, mechanisms of importance for the development of atherosclerosis (Guo et al., 2001). Here, SOD2 is linked to atherosclerosis.