DPP4 and myocardial infarction: Additionally, previous studies from our laboratory (dos Santos et al., 2013) and others (Sauvé et al., 2010; Gomez et al., 2012; Shigeta et al., 2012; Aoyama et al., 2016) have demonstrated that genetic deletion or pharmacologic inhibition of DPPIV prevents the onset of HF after myocardial infarct/injury in rodents and large animal models.