For the six genes in the violet module of AD APOE ε4 carriers, hsa-miR-194, hsa-miR-199a-5p, hsa-miR-199b-5p, hsa-miR-30a, hsa-miR-30d, and hsa-miR-30e were indicated to bind with at least four of the five hub genes except GNB3 (Supplementary Table S25). This evidence concerns the gene APOE and Alzheimer disease.