APOE and Alzheimer disease: Two conserved promoter motifs with extremely low conservative P-values (P = 6.539 × 10-122 for the 49-base motif and P = 1.003 × 10-74 for the 14-base motif) were detected for the genes of the complete graph of the violet module of AD APOE ε4 carriers (Figures 6A,B), and an adenine-rich conserved promoter motif was identified with a P-value of 1.935 × 10-125 among the genes of the complete graph of the light cyan module of AD APOE ε4 non-carriers (Figure 6C).