ISOC1 and Alzheimer disease: As shown in Figure 3A, the mRNA expressions of all six genes (ISOC1, ENO3, GDF10, GNB3, XPO4 and ACLY) in the complete graph of the violet module of AD APOE ε4 carriers demonstrated a similar time-dependent patterns in neurons treated with physiological concentration of APOE ε4, whereas, no such patterns were observed in neurons treated with APOE ε3 or in untreated neurons (Figures 3B,C).