APOE and Alzheimer disease: The permutation-based preservation statistic, Zsummary, demonstrated that the Zsummary statistics of the identified three modules were all less than 2 when assessing the violet and dark magenta modules of AD APOE ε4 carriers in AD APOE ε4 non-carriers and control APOE ε4 carriers and when assessing the light cyan module of AD APOE ε4 non-carriers in AD APOE ε4 carriers and control APOE ε4 non-carriers, showing no evidence of module preservation in these sub-datasets (Figure 1; Supplementary Table S2).