DISC1 and schizophrenia: In support of this statement, one study found that MIA induced a phenotype characterized by strong social impairment specifically in mice overexpressing a double negative form of DISC1 (Ibi et al., 2010), a gene strongly associated to Schizophrenia and ASD (Ishizuka et al., 2006; Crepel et al., 2010; Zheng et al., 2011; Turner et al., 2016).