INS and hyperandrogenism: Given the fact that insulin+hCG-treated rats exhibit peripheral insulin resistance (Fig. 1), hyperandrogenism (Table 2), ovarian defects (Tables 1 and 2), and disrupted estrous cyclicity (Table 1 and Supplemental Table 2)22, 23, 24, 25, 26 in a similar manner as human PCOS, it is worth examining whether uterine dysfunction occurs in these rats in addition to both the metabolic and ovarian features of PCOS.