The most significantly enriched KEGG pathways in hypo-C-DMRs were “B cell receptor (BCR) signaling pathway” (adjusted p value (p.adj) = 2.21E-02), “p53 signaling pathway” (p.adj = 3.69E-02), and “pathways in cancer” (p.adj = 3.69E-02), along with a few other signaling pathways and pathways involved in cancer. The gene discussed is TP53; the disease is cancer.