Materials and methods: Human melanoma A375 and M14 cell lines expressing different levels of uPAR and comparable levels of FPR-1 on cell surface, were analyzed for their ability to move toward chemotactic gradients, to invade extra-cellular matrix and to disrupt endothelial monolayers using the Real Time Cell Analysis System and the xCELLigence technology [9]. This evidence concerns the gene PLAUR and melanoma.