CD8A and neoplasm: Therefore, we elaborated a possible work flow approach based on the LEAN management system: phase 1: CRC diagnosis, block selection and digital order of CD3 and CD8 by the pathologist; phase 2: immunohistochemical staining and scanning by the immunohistochemistry laboratory; phase 3: definition of the tumor area, calculation and reporting of the results by the pathologist; phase 4: discussion of the results at the interdisciplinary CRC board.