Collectively, this data revealed complex responses to the concurrent inhibition of anti-apoptotic proteins and mTOR-mediated signaling in hypoxic CRC cell lines, where pro-survival responses were elicited in parallel with the intended anti-proliferative effects in KRAS/PIK3CA-mutant entities in particular, a finding that should be of note if considering the combinatory targeting of multiple pathways in CRC treatment. This evidence concerns the gene KRAS and colorectal carcinoma.