BRAF and colorectal carcinoma: Since Faber and co-workers found that the combination of ABT-263, a structurally related compound to ABT-737, with AZD8055 at concentrations of 50–500 nM for 72 h caused apoptosis in CRC cell lines with KRAS or BRAF mutation [9], we next investigated inhibitory effects on cell viability when combining AZD8055 at 0.10 μM with ABT-737 for 72 h.