ESR2 and melanoma: This work was supported by Fondazione Banca del Monte di Lombardia (‘Molecular bases for the development of chemopreventive and therapeutic strategies in melanoma: estrogen receptor beta, epigenetics, and tocotrienols’) (PL) and Comitato Emme Rouge Onlus (‘Evaluation of the antitumor activity of natural compounds tocotrienols and possible combination with molecular targeted therapies in melanoma’) (PL).