MYC levels further increase at the transition to frank lymphomas and there is clear evidence for further increases in MYC levels during progression of several tumor entities, as for example in APC-mutant colorectal tumors (Kress et al., 2011; Myant and Sansom, 2011; Siemens et al., 2011). The gene discussed is MYC; the disease is colorectal neoplasm.