TARDBP and amyotrophic lateral sclerosis: For example, mutations in fused in sarcoma protein (FUS), Tar DNA-binding protein 43 (TDP-43) and heterogeneous nuclear ribonucleoproteins (hnRNPA1/hnRNPA2B1) alter their localization or promote aggregation, and have been linked to amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD)3, 4, 5, 6, 7.