For example, mutations in fused in sarcoma protein (FUS), Tar DNA-binding protein 43 (TDP-43) and heterogeneous nuclear ribonucleoproteins (hnRNPA1/hnRNPA2B1) alter their localization or promote aggregation, and have been linked to amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD)3, 4, 5, 6, 7. This evidence concerns the gene HNRNPA2B1 and amyotrophic lateral sclerosis.