In contrast to the apparently beneficial effects seen in atherosclerotic plaques, Angptl4−/−Ldlr−/− mice exhibited a severe phenotype with peritonitis, depleted fat deposition in the gut, decreased body weight and severe gut inflammation (Fig. 2b–d), consistent with previous reports of Angptl4−/− mice fed a high-fat diet27, 41. This evidence concerns the gene ANGPTL4 and peritonitis.