ANGPTL4 and Increased total leukocyte count: These observations suggest that the leukocytosis observed in the Angptl4−/− BM transplanted mice is possibly an exaggeration of existing differences in the HSPC population in Angptl4−/− mice, whereby these mice have increased CMPs with higher proliferation potential and better survival and thus have the potential to give rise to more progenies including neutrophils and monocytes.