To test this hypothesis, in addition to the renal cell carcinoma cell line RCC4, we used another renal cancer cell line, UOK121, in which VHL is epigenetically silenced, along with the RCC4 + VHL and UOK121 + VHL cell lines, which were stably transfected with functional VHL. This evidence concerns the gene SLC49A4 and hereditary clear cell renal cell carcinoma.