F2 and anemia (phenotype): Of the 34 cats initially enrolled, ten cats were excluded due abnormal results of echocardiographic examinations (n = 4), anemia (n = 1), increased plasma creatinine concentrations (n = 1), prolonged prothrombin time (n = 1), thrombocytopenia (n = 1), and decreased fibrinogen levels (n = 1).