We, and others, recently generated and characterized mouse models of the 15q13.3 microdeletion syndrome by deleting the orthologous genomic region on mouse chromosome 7.9, 10 Behavioral characterization of the 15q13.3 mouse models, Df(h15q13)+/−, revealed schizophrenia-, autism- and epilepsy-related phenotypes.9, 10. The gene discussed is CFD; the disease is epilepsy.