For patient of the T2DM group, percentages of PD-1+ CD4+ T cells and PD-1+ CD8+ T cells were both positively correlated with Hs-CRP levels (r = 0.452 and 0.376 respectively, P<0.001 for both) (Fig 2a and 2b), but showed no significant correlation with HbA1c, blood glucose levels on admission (P>0.05). This evidence concerns the gene CD4 and type 2 diabetes mellitus.