In the present study, patients with lupus nephritis with poor efficiency did not reach complete remission/partial remission with prednisone 0.8–1.0 mg/kg+cyclophosphamide 1 g/m2 ×3 m, and the urine and serum MCP-1 and serum RAGE showed lower levels in the patients with poor efficiency. Here, CCL2 is linked to lupus nephritis.