The MCP-1, fractalkine and RAGE levels indicated different levels for different pathological types of lupus nephritis, and the difference in the levels of urine and serum MCP-1 in the two groups was significant (urine MCP-1: P = 0.008; serum MCP-1: P = 0.02; urine Fkn: P = 0.02; serum Fkn: P = 0.006; serum RAGE: P = 0.0053). The gene discussed is CX3CL1; the disease is lupus nephritis.