PCOLCE and Hepatic fibrosis: Under the experimental conditions we used, considerable liver fibrosis (increased amounts of collagen I and PCPE-1 in the liver) was evident after 6 weeks of CCl4 administration (Fig 4A and 4B; Fig 5A, 5B and 5E), which was accompanied by about 34% increase in the plasma levels of PCPE-1 (Fig 4C), thus corroborating the results gained using mdx mice as a model.