Here we report that the levels of Sam68, phospho-p65 (indicative of NF-κB activation), anti-apoptotic molecules Bcl-XL and XIAP are all elevated in colon tumors in comparison to adjacent normal tissue derived from genetically susceptible Apcmin716/+ mice and human colon cancer patients. This evidence concerns the gene KHDRBS1 and malignant colon neoplasm.