Elevated Sam68 levels correlate with tumor progression and poor prognosis in multiple cancer patients and overexpression of Sam68 has been proposed as a prognostic marker (Chen et al., 2012; Liao et al., 2013; Song et al., 2010; Zhang et al., 2009); however, the significance of Sam68 in tumorigenesis is still obscure. The gene discussed is KHDRBS1; the disease is neoplasm.