In line with the attenuated NF-κB activation and anti-apoptotic transcription, Olaparib or PJ-34 treatment triggered colon cancer cells to undergo spontaneous apoptosis, as conveyed by Annexin-V staining (Figure 7G and Figure 7—figure supplement 1C–D), which mirrors the impact of Sam68 knockdown on the survival of these cell lines (Figure 6G–H). The gene discussed is NFKB1; the disease is malignant colon neoplasm.