To ascertain whether Sam68 deletion reduces colon tumor formation as a result of the defect in PARP1 activation and PARylation, we assessed the impact of the PARP inhibitor, Olaparib, on phosphor-p65 and Bcl-XL levels and colon tumor development in Apcmin716/+ mice. The gene discussed is PARP1; the disease is colonic neoplasm.