Importantly, down-regulation of PARP1 or p65 sensitized colon cancer cells to undergo spontaneous apoptosis (Figure 7—figure supplement 1F–G), which mirrors the effects of PARP1 inhibition (Figure 7G and Figure 7—figure supplement 1C–D) and Sam68 knockdown (Figure 6G–H and Figure 7—figure supplement 1E). Here, PARP1 is linked to colonic neoplasm.