Of note, the positive correlation between Sam68 levels and PAR levels, as well as phospho-p65 levels in human colon cancers suggests that Sam68 could be essential for the development and survival of colon cancer, considering the pivotal function of Sam68 in orchestrating the intrinsic DNA damage-initiated NF-κB signaling and transactivation. Here, NFKB1 is linked to colonic neoplasm.