It is widely accepted that massive intrinsic DNA damage occurs during rapid DNA replication and proliferation in cancer cells (Hanahan and Weinberg, 2011; Rouleau et al., 2010), and that the dysregulation of NF-κB and apoptosis play crucial roles in cancer development and progression (Townson et al., 2003; Zubair and Frieri, 2013). The gene discussed is NFKB1; the disease is cancer.