MAPT and Parkinson disease: After further adjusting for MAPT total level of expression, this isoform remained associated with global parkinsonism (β = -0.0165, p = 0.012, adjusted for age, sex, study and pathology) and bradykinesia (β = -0.0276, p = 0.011, adjusted for age, sex, study and pathology) (S3 Fig).