MAPT and multiple system atrophy: MAPT H1 and its sub haplotype H1c are reported to be associated with increased risk for certain age-related neurodegenerative diseases, including progressive supranuclear palsy (PSP) [8–11], corticobasal degeneration (CBD) [10,11], Multiple System Atrophy (MSA) [12] and Parkinson’s disease (PD) [13,14].