Considering the previous demonstration that the interaction of paracoccin with TLR2 and TLR4 on macrophages modulates immunity and positively interferes in the PCM course (Alegre et al., 2014; Alegre-Maller et al., 2014), herein we detailed additional events triggered by paracoccin in those cells. This evidence concerns the gene TLR2 and paracoccidioidomycosis.