It was demonstrated that the size and number of these fenestrae are reduced in inwardly remodeled vessels, that is vessels with a reduced passive luminal diameter due to structural changes, from angiotensin-II treated rodents, and this reduction coincided with an increase in mesenteric arterial stiffness and the development of hypertension in rats (Briones et al., 2009). Here, AGT is linked to Hypertension.