It was demonstrated that the size and number of these fenestrae are reduced in inwardly remodeled vessels, that is vessels with a reduced passive luminal diameter due to structural changes, from angiotensin-II treated rodents, and this reduction coincided with an increase in mesenteric arterial stiffness and the development of hypertension in rats (Briones et al., 2009). This evidence concerns the gene AGT and hypertensive disorder.