MFN2 and Charcot-Marie-Tooth disease type 2: Dominant mutations in Mitofusin 2 (MFN2) are the primary cause of axonal degeneration in Charcot-Marie-Tooth Neuropathy (CMT2), and MFN2 has been implicated in the fusion and transport of mitochondria in neurons (Chen et al., 2003; Züchner et al., 2004; Baloh et al., 2007).