HTT and Huntington disease: The characteristic aggregates observed in HD patients are primarily constituted by small fragments of Htt Exon 1 that are most likely generated by abortive degradation attempts or the translation of an Exon 1-only mRNA produced due to aberrant splicing (Suhr et al., 2001; Chow et al., 2012; Sathasivam et al., 2013).